When I was first aware that I had been laid low by the disease, I felt a need, among other things, to register a strong protest against the word “depression.” Depression, most people know, used to be termed “melancholia,” a word which appears in English as early as the year 1303 and crops up more than once in Chaucer, who in his usage seemed to be aware of its pathological nuances. Styron, who first descended into clinical depression at the age of sixty and describes himself as “one who has suffered from the malady in extremis yet returned to tell the tale,” considers the cultural baggage of this “veritable howling tempest in the brain,” propelled by “the intermingled factors of abnormal chemistry, behavior and genetics”: No one has captured this perennial plague of the human spirit with greater vividness and acuity than William Styron (June 11, 1925–November 1, 2006) in Darkness Visible ( public library) - his trenchant 1990 memoir of depression. And yet, even as scientists are exploring the evolutionary origins of depression and the role REM sleep may play in it, understanding and articulating the experience of the disease remains a point of continual frustration for those afflicted and a point of continual perplexity for those fortunate never to have plummeted to the bottom of the well. In a piercing letter to his brother, Vincent van Gogh captured the mental anguish of depression in a devastatingly perfect visceral metaphor: “One feels as if one were lying bound hand and foot at the bottom of a deep dark well, utterly helpless.” Anyone who has suffered from this debilitating disease knows that the water in that well is qualitatively, biochemically different from the water in the puddle of mere sadness.
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